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XEN103

CAT: 0804-HY-111315Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111315Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XEN103 is a SCD1 inhibitor, with IC50s of 14 nM and 12 nM for mSCD1 and SCD1 in HepG2 cell. XEN103 can be used for research of obesity and type 2 diabetes. XEN103 also induces sebaceous gland atrophy in mice[1][2].
CAS Number
840489-44-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Stearoyl-CoA Desaturase (SCD)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/xen103.html
Smiles
O=C(C1=NN=C(N2CCN(CC2)C(C3=CC(F)=CC=C3C(F)(F)F)=O)C=C1)NCCC4CC4
Molecular Formula
C22H23F4N5O2
Molecular Weight
465.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zhang Z, et al. Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome. J Med Chem. 2013 Jan 24;56 (2) :568-83.|[2]Meingassner JG, et al. Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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