Centmitor-1

CAT: 0804-HY-124519Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-124519Size:1 Each

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Description

Centmitor-1 (Cent-1) is a mitotic arrest inducer. Centmitor-1 modulates microtubule plus-ends and reduced microtubule dynamics. In cells, Centmitor-1 causes mitotic arrest characterized by chromosome alignment defects, multipolar spindles, centrosome fragmentation, and activated spindle assembly checkpoint[1].

CAS Number

331749-88-3

Product Name Alternative

Cent-1

UNSPSC

12352005

Hazard Statement

H302-H410

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/centmitor-1.html

Smiles

O=C1C2=C(N(CC(N/N=C/C3=CC=C(C(Br)=C3)O)=O)C4=C1C=CC=C4)C=CC=C2

Molecular Formula

C22H16BrN3O3

Molecular Weight

450.28

Precautions

P264-P270-P273-P330-P391-P501

References & Citations

[1]Jenni H E Mäki-Jouppila, et al. Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na. Mol Cancer Ther. 2014 May;13 (5) :1054-66.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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MBS5780419	Centmitor-1
OF59775-01	1,1,1,1,1-Kestoheptaose
N2864-5.1	1,1,1,1-Kestohexaose
112040	1,1,1,1-Kestohexose
410417-01	1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-01	1-Iodobicyclo[1.1.1]pentane
OR312388	1-Phenylbicyclo[1.1.1]pentane
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Centmitor-1

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