(D-Arg8)-Inotocin

(D-Arg8)-Inotocin

• CAS Number: 745816-74-4
• UNSPSC Description: (D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V1aR), with a Ki of 1.3 nM. (D-Arg8)-Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R[1].
• Target Antigen: Vasopressin Receptor
• Type: Peptides
• Related Pathways: GPCR/G Protein
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/d-arg8-inotocin.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H]1NC([C@@H](NC([C@](NC([C@](NC([C@@H](NC([C@H](CSSC1)N)=O)CC(C)C)=O)([H])[C@@H](C)CC)=O)([H])[C@H](O)C)=O)CC(N)=O)=O)N2[C@@H](CCC2)C(N[C@H](CCCNC(N)=N)C(NCC(N)=O)=O)=O
• Molecular Weight: 973.17
• References & Citations: [1]Giglio MGD, et, al. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Sci Rep. 2017 Feb 1;7:41002.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported