(D-Arg8)-Inotocin

• UNSPSC Description:

  (D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V1aR), with a Ki of 1.3 nM. (D-Arg8)-Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R[1].

• Target Antigen:

  Vasopressin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-arg8-inotocin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H]1NC([C@@H](NC([C@](NC([C@](NC([C@@H](NC([C@H](CSSC1)N)=O)CC(C)C)=O)([H])[C@@H](C)CC)=O)([H])[C@H](O)C)=O)CC(N)=O)=O)N2[C@@H](CCC2)C(N[C@H](CCCNC(N)=N)C(NCC(N)=O)=O)=O

• Molecular Weight:

  973.17

• References & Citations:

  [1]Giglio MGD, et, al. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Sci Rep. 2017 Feb 1;7:41002.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  745816-74-4