ML133 HCl

• Background:

  A potent and selective blocker of the inwardly rectifying Kir2 potassium channel, IC50s = 1.8, 2.8, 2,9, and 4.0 µM for Kir2.1, Kir2.6, Kir2.2, and Kir2.3, respectively (1). Intrathecal injection of ML133 attenuated the proliferation of microglia and neuropathic pain behaviors after nerve injury (2). ML133 inhibits microglial priming pointing to Kir2.1 channels as a new therapeutic target for neuronal damage (3). Moreover, treatment with ML133 one hour post-injury was sufficient to improve neuronal survival in a traumatic brain injury human organoid model (4).

• Description:

  Potassium channel Blocker- Neuroprotective

• Product Name Alternative:

  N-[ (4-Methoxyphenyl) methyl]-1-naphthalenemethanamine, hydrochloride

• UNSPSC:

  41116105

• Type:

  Blocker

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurotransmission | Neurotransmitter Receptors | Ion Channels | Potassium Channels

• Purity:

  >98% (HPLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  White powder

• Solubility:

  May be dissolved in DMSO (32 mg/ml); or water (10 mg/ml, warm)

• Molecular Formula:

  C19H19NO • HCl

• Molecular Weight:

  313.8

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Wang H.R. et al. 2011. ACS Chem. Biol. 6:845. 2. Gattlen C. et al. (2020) Glia 68:2119. 3. Spencer N.G. et al. (2016) PLoS One. 11(9):e0162497. 4. Lai J.D. et al. 2024. Cell Stem Cell 31:519.

• CAS Number:

  1222781-70-5