Amlodipine (besylate) (Standard)

Amlodipine (besylate) (Standard)

• CAS Number: 111470-99-6
• UNSPSC Description: Amlodipine (besylate) (Standard) is the analytical standard of Amlodipine (besylate). This product is intended for research and analytical applications. Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer[1][2][3].
• Target Antigen: Calcium Channel
• Type: Reference Standards
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/amlodipine-besylate-standard.html
• Solubility: DMSO : ≥ 45 mg/mL
• Smiles: O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC.O=S(C3=CC=CC=C3)(O)=O
• Molecular Weight: 567.05
• References & Citations: [1]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12.|[2]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87.|[3]Kishen G. Bulsara, et al. Amlodipine.|[4]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586.
• Shipping Conditions: Room temperature
• Clinical Information: Launched