Amlodipine-d4 (besylate)

Amlodipine-d4 (besylate)

• UNSPSC Description: Amlodipine-d4 (besylate) is the deuterium labeled Amlodipine besylate. Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer[1][2][3].
• Target Antigen: Calcium Channel; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling;Others
• Field of Research: Cancer; Cardiovascular Disease
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=C([2H])C([2H])=C([2H])C([2H])=C2Cl)OCC.O=S(C3=CC=CC=C3)(O)=O
• Molecular Weight: 571.08
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Kishen G. Bulsara, et al. Amlodipine.|[3]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586.|[4]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12.|[5]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported