NPC 17731

• UNSPSC Description:

  NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC50 of 23 and 29 nM, respectively[1].

• Target Antigen:

  Bradykinin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/npc-17731.html

• Smiles:

  O=C([C@@H]1N(C[C@H](C1)OCCC)C([C@H](CO)NC([C@@H](NC(CNC([C@H]2N(C[C@@H](C2)O)C([C@H]3N(CCC3)C([C@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)N5[C@]6([H])[C@](CCCC6)([H])C[C@H]5C(N[C@H](C(O)=O)CCCNC(N)=N)=O

• Molecular Weight:

  1294.50

• References & Citations:

  [1]Y S Medeiros, et al. Competitive and selective antagonistic action of NPC 17731 on bradykinin-induced relaxant and contractile responses of the guinea pig isolated ileum. Gen Pharmacol. 1995 Nov;26(7):1507-11.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  147267-10-5