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Huwentoxin I

CAT: 0804-HY-P5179Size: 1 EachDry Ice: NoHazardous: No
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Description
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC50 values of 66.1 and 4.80 nM, respectively[1].
CAS Number
769973-37-7
Product Name Alternative
HWTX-I
UNSPSC
12352209
Target
Calcium Channel; Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/huwentoxin-i.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)C)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CCCCN)=O)CC4=CNC5=CC=CC=C45)=O)CCCCN)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)CCCCN)=O)=O)CCC1)=O)[C@@H](C)O)=O)CSSC[C@H](NC6=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC7=CNC8=CC=CC=C78)=O)CCCCN)=O)CC9=CNC=N9)=O)CCCCN)=O)CC(O)=O)=O)CO)=O)=O)C)=O)CC(O)=O)=O)CC%10=CC=CC=C%10)=O)C(C)C)=O)=O)CCCCN)=O)CSSC[C@H](NC2=O)C(N%11[C@H](C(N[C@H](C(N[C@H](C(N[C@H]6C(C)C)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCC%11)=O
Molecular Formula
C161H246N48O44S6
Molecular Weight
3750.36
References & Citations
[1]Wang M, et al. The effects of huwentoxin-I on the voltage-gated sodium channels of rat hippocampal and cockroach dorsal unpaired median neurons. Peptides. 2012 Mar;34 (1) :19-25.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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