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Spongionellol A

CAT: 0804-HY-N10491Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10491Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer[1].
UNSPSC
12352005
Target
P-glycoprotein
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spongionellol-a.html
Solubility
10 mM in DMSO
Smiles
CC(O[C@H]1[C@]23[C@@](CC[C@H]([C@@]2([H])C(O[C@H]3OC(C)=O)OC(C)=O)C(OC)=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])C1)C)=O
Molecular Formula
C27H40O9
Molecular Weight
508.60
References & Citations
[1]Sergey A Dyshlovoy, et al. New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein. Sci Rep. 2022 Aug 9;12 (1) :13570.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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