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BMPR2-IN-1

CAT: 0804-HY-154970Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-154970Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMPR2-IN-1 (Compound 8a) is a BMPR2 inhibitor with an IC50 of 506 nM and a KD of 83.5 nM. BMPR2-IN-1 can be used for research of pulmonary arterial hypertension, Alzheimer’s disease and cancer[1].
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bmpr2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1NCCC2=CC=C(NC3=NC(NC4=NNC1=C4)=CC=N3)C=C2
Molecular Formula
C16H15N7O
Molecular Weight
321.34
References & Citations
[1]Amrhein JA, et al. Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. ACS Med Chem Lett. 2023 May 30;14 (6) :833-840.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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