Bisphenol C

• Description :

  Bisphenol C is an estrogen receptor-α (ERα) agonist and an ERβ antagonist, with IC50 values of 2.65 nM for ERα and 1.94 nM for ERβ. Bisphenol C is a material of manufacturing polyester polymers like polycarbonate, is widely used in daily items like water bottles, food packaging, textile and so on[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Estrogen Receptor/ERR; mTOR

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/bisphenol-c.html

• Purity :

  98.0

• Smiles :

  CC1=CC(=CC=C1O)C(C)(C)C2=CC=C(C(=C2)C)O

• Molecular Formula :

  C17H20O2

• Molecular Weight :

  256.34

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Xiaohui Liu, et al. Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding. PLoS One. 2021 Feb 9;16 (2) :e0246583.|[2]Su K, et al. Bisphenol C Induces Cardiac Developmental Defects by Disrupting m6A Homeostasis. Environ Sci Technol. 2024 Oct 1;58 (39) :17259-17269. |[3]Liu J, et al. Bisphenol C induces developmental defects in liver and intestine through mTOR signaling in zebrafish (Danio rerio) . Chemosphere. 2023 May;322:138195.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERα

• CAS Number :

  [79-97-0]