Chlorambucil

CAT: 0804-HY-13593-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13593-01Size:100 mg
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Description
Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].
CAS Number
[305-03-3]
Product Name Alternative
CB-1348; WR-139013
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335, H350
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Chlorambucil.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(O)CCCC1=CC=C(N(CCCl)CCCl)C=C1
Molecular Formula
C14H19Cl2NO2
Molecular Weight
304.21
Precautions
H301, H315, H319, H335, H350
References & Citations
[1]Guo JX, et al. Synergistic effects of chlorambucil and TRAIL on apoptosis and proliferation of Raji cells. Eur Rev Med Pharmacol Sci. 2017 Oct;21 (20) :4703-4710.|[2]Salem FS, et al. Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma-bearing mice. Vet Ital. 2011 Jan-Mar;47 (1) :89-95.|[3]Mohamed D, et al. Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem Res Toxicol. 2009;22 (8) :1435-1446.|[4]Birnbaum AD, et al. Chlorambucil and malignancy. Ophthalmology. 2010;117 (7) :1466-1466.e1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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