Chlorambucil

• Description:

  Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

• Product Name Alternative:

  CB-1348; WR-139013

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H315, H319, H335, H350

• Target:

  DNA Alkylator/Crosslinker

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Chlorambucil.html

• Concentration:

  10mM

• Purity:

  99.84

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(O)CCCC1=CC=C(N(CCCl)CCCl)C=C1

• Molecular Formula:

  C14H19Cl2NO2

• Molecular Weight:

  304.21

• Precautions:

  H301, H315, H319, H335, H350

• References & Citations:

  [1]Guo JX, et al. Synergistic effects of chlorambucil and TRAIL on apoptosis and proliferation of Raji cells. Eur Rev Med Pharmacol Sci. 2017 Oct;21 (20) :4703-4710.|[2]Salem FS, et al. Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma-bearing mice. Vet Ital. 2011 Jan-Mar;47 (1) :89-95.|[3]Mohamed D, et al. Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem Res Toxicol. 2009;22 (8) :1435-1446.|[4]Birnbaum AD, et al. Chlorambucil and malignancy. Ophthalmology. 2010;117 (7) :1466-1466.e1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  305-03-3