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Chlorambucil-d8-1

CAT: 0804-HY-13593S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13593S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chlorambucil-d8-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].
Product Name Alternative
CB-1348-d8-1; WR-139013-d8-1
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(O)CC([2H])([2H])C([2H])([2H])C1=C([2H])C([2H])=C(N(CCCl)CCCl)C([2H])=C1[2H]
Molecular Formula
C14H11D8Cl2NO2
Molecular Weight
312.26
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Guo JX, et al. Synergistic effects of chlorambucil and TRAIL on apoptosis and proliferation of Raji cells. Eur Rev Med Pharmacol Sci. 2017 Oct;21 (20) :4703-4710.|[3]Salem FS, et al. Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma-bearing mice. Vet Ital. 2011 Jan-Mar;47 (1) :89-95.|[4]Mohamed D, et al. Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem Res Toxicol. 2009;22 (8) :1435-1446.|[5]Birnbaum AD, et al. Chlorambucil and malignancy. Ophthalmology. 2010;117 (7) :1466-1466.e1.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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