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APE1 Rabbit mAb [KD Validated] Antibody

CAT: 0013-GTR18334883-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0013-GTR18334883-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ape1 initiates the repair of abasic sites and is essential for the base excision repair (BER) pathway. Repair activities of Ape1 are stimulated by interaction with XRCC1, another essential protein in BER. Ape1 functions as a redox factor that maintains transcription factors in an active, reduced state but can also function in a redox-independent manner as a transcriptional cofactor to control different cellular fates such as apoptosis, proliferation and differentiation.
Product Name Alternative
DNA- (apurinic or apyrimidinic site) lyase; APEX nuclease; APEN; AP endonuclease 1; APE-1; APEX1; APE; APE1; APEX; APX; HAP1; REF1
UniProt
P27695
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human APE1
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Affinity-chromatography
Dilution
WB 1:1000~1:5000 IHC 1:50~1:200
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
IHC, WB
Host or Source
Rabbit
Isotype
Rabbit IgG

UniProtKB · P27695

DNA repair nuclease/redox regulator APEX1

APEX1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P27695
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APEX1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.11.2, 3.1.21.-
Processing
—
Secondary accessions
Q969L5, Q99775
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationCleavage on pair of basic residuesDisulfide bondPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

ActivatorDNA-bindingEndonucleaseExonucleaseHydrolaseNucleaseRepressorRNA-binding

Cellular component

CytoplasmEndoplasmic reticulumMitochondrionNucleus

Biological process

DNA damageDNA recombinationDNA repairTranscriptionTranscription regulation

Ligand

MagnesiumMetal-binding

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