Nicotinamide riboside (chloride)

Nicotinamide riboside (chloride)

• CAS Number: 23111-00-4
• UNSPSC Description: Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].
• Target Antigen: Endogenous Metabolite; Sirtuin
• Type: Natural Products
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
• Field of Research: Metabolic Disease; Neurological Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/nicotinamide-riboside-chloride.html
• Purity: 99.90
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 125 mg/mL (ultrasonic)
• Smiles: NC(C1=C[N+]([C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)=CC=C1)=O.[Cl-]
• Molecular Weight: 290.703
• References & Citations: [1]Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.|[2]Bing Gong, et al. Nicotinamide Riboside Restores Cognition Through an Upregulation of Proliferator-Activated Receptor-γ Coactivator 1α Regulated β-Secretase 1 Degradation and Mitochondrial Gene Expression in Alzheimer's Mouse Models. Neurobiol Aging. 2013 Jun;34(6):1581-8.|[3]Collin D Heer, et al. Coronavirus and PARP Expression Dysregulate the NAD Metabolome: A Potentially Actionable Component of Innate Immunity. bioRxiv. 2020 Apr 30;2020.04.17.047480.Basic Res Cardiol. 2024 Mar 25.|Curr Issues Mol Biol. 2024 Feb 1;46(2):1291-1307.|Exp Eye Res. 2024 Oct 15:248:110126.|Invest Ophthalmol Vis Sci. 2024 Jul 1;65(8):1.|Nat Commun. 2023 Jan 16;14(1):240.|Toxicol Appl Pharmacol. 2024 Aug 9:117066.|ACS Appl Mater Interfaces. 2024 Apr 16.|Cell Biosci. 2021 Nov 10;11(1):192.|Cells. 2023 Oct 2, 12(19), 2396.|Commun Biol. 2023 Mar 2;6(1):235.|FASEB J. 2022 Jul;36(7):e22418.|FASEB J. 2024 Apr 15;38(7):e23600.|Mol Ther. 2022 Sep 21;S1525-0016(22)00567-6.|Redox Biol. 2022 Oct 11;57:102507.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported