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Thapsigargicin

CAT: 0804-HY-N11691Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N11691Size:1 Each
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Description
Thapsigargicin (Thapsigargicine) is a activator of mast cells and leukocytes. Thapsigargicin induces histamine release from rat peritoneal mast cells and human basophil leukocytes. Thapsigargicin increases the cytoplasmic free calcium level in intact human blood platelets[1].
CAS Number
67526-94-7
Product Name Alternative
Thapsigargicine
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/thapsigargicin.html
Solubility
10 mM in DMSO
Smiles
CC1=C2[C@]([C@](C)(C[C@@H]([C@]3([C@@]2([H])OC([C@]3(O)C)=O)O)OC(CCC)=O)OC(C)=O)([H])[C@@H]([C@H]1OC(/C(C)=C\C)=O)OC(CCCCC)=O
Molecular Formula
C32H46O12
Molecular Weight
622.70
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Ali H, et al. The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. Br J Pharmacol. 1985 Jul;85 (3) :705-12.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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