S65487

S65487

• CAS Number: 1644600-79-2
• UNSPSC Description: S65487 (VOB560), a potent and selective BCL-2 inhibitor, is a proagent of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities[1][2].
• Target Antigen: Apoptosis; Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s65487.html
• Smiles: O=C(C1=C(C)N(C)C(C2=C(C=CC(Cl)=C2)C(N3[C@@H](CC4=CC=CC=C4C3)CN5CCOCC5)=O)=C1)N(C6=CC=C(C=C6)O)C7=C(C)N(C)C(C#N)=C7
• Molecular Weight: 717.26
• References & Citations: [1]Arnaud Le Tiran, et al. Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax. Cancer Research. July 2021.|[2]American Association for Cancer Research, AACR. 2021.4.10-15.
• Shipping Conditions: Room Temperature