S65487

• Target:

  Apoptosis|||Bcl-2 Family|||Others

• Related Pathways:

  Apoptosis|||Others

• Purity:

  0.9903

• Bioactivity:

  S65487 (VOB560) is a potent and selective inhibitor of the anti-apoptotic protein Bcl-2, displaying activity not only against the wild-type protein but also against clinically relevant BCL-2 mutations such as G101V and D103Y. S65487 demonstrates poor affinity toward other Bcl-2 family members, including MCL-1, BFL-1, and BCL-XL, which underlines its selectivity profile. S65487 induces apoptosis in cancer cells and exhibits robust anticancer activities in preclinical studies.

• Smiles:

  N(C(=O)C=1C=C(N(C)C1C)C2=C(C(=O)N3[C@H](CN4CCOCC4)CC=5C(C3)=CC=CC5)C=CC(Cl)=C2)(C=6C=C(C#N)N(C)C6C)C7=CC=C(O)C=C7

• Molecular Formula:

  C41H41ClN6O4

• Molecular Weight:

  717.26

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1644600-79-2