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Skepinone-L

CAT: 0804-HY-15300-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15300-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Skepinone-L (CBS3830), a chemical probe, is a selective p38 mitogen-activated protein kinase inhibitor.
CAS Number
1221485-83-1
Product Name Alternative
CBS3830
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; p38 MAPK
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Skepinone-L.html
Purity
99.79
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1C2=CC(OC[C@@H](CO)O)=CC=C2CCC3=C1C=CC(NC4=CC=C(C=C4F)F)=C3
Molecular Formula
C24H21F2NO4
Molecular Weight
425.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Koeberle, Solveigh C.; Romir, Johannes; Fischer, Stefan et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nature Chemical Biology (2012), 8 (2), 141-143.|[2]Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter et al. Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Journal of Medicinal Chemistry (2012), 55 (12), 5868-5877.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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A3824-10Skepinone-L
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