Azide-PEG5-Tos

Azide-PEG5-Tos

• CAS Number: 236754-49-7
• UNSPSC Description: Azide-PEG5-Tos is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azide-PEG5-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/azide-peg5-tos.html
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: [N-]=[N+]=NCCOCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
• Molecular Weight: 417.48
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported