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Pridopidine

CAT: 0400-SIH-626-25MGSize: 25 mgDry Ice: NoHazardous: No
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CAT#:0400-SIH-626-25MGSize:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia (1,2). Able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (“dopamine stabilizer”) (3). More recent studies have attributed pridopidine’s effects to its being a more potent sigma-1 ligand than a D2 ligand (4,5). Displays neuroprotective/restorative effects (6,7) and ameliorates central features of amyotrophic lateral sclerosis pathology (8) in a sigma-1-mediated manner.
Description
Neuroprotective
CAS Number
346688-38-8
Product Name Alternative
4- (3- (Methylsulfonyl) phenyl) -1-propylpiperidine; ACR16
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | ALS Disease
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (10 mg/ml)
Molecular Formula
C15H23NO2S
Molecular Weight
281.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. F Pettersson et al. 2010 J. Med. Chem. 53:2510. 2. S Natesan et al. 2006 J. Pharmacol. Exp. Ther. 318:810. 3. T Dyhring et al. 2010 Eur. J. Pharmacol. 628:19. 4. K Sahlholm et al. 2015 Psychopharmacology (Berl) 232:3443. 5. K Sahlholm et al. 2013 Mol. Psychiatry 18:12. 6. V Francardo et al. 2019 Neurotherapeutics 16:465. 7. D Ryskamp et al. 2017 Neurobiol. Dis. 7 97(Pt A):46. 8. A Ionescu et al. 2019 Cell Death Dis. 10:210.

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