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Golcadomide

CAT: 0804-HY-146237-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-146237-01Size:1 mg
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Description
Golcadomide (CC-99282) is a potent and orally active CRBN E3 ligase modulator (CELMoD) . Golcadomide interacts with the CRL4 CRBN E3 ubiquitin ligase substrate receptor CRBN, inducing the recruitment and ubiquitin-mediated proteasomal degradation of the transcription factors Ikaros and Aiolos. Golcadomide shows potential for research in cancer-related fields, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) [1][2].
CAS Number
2379572-34-4
Product Name Alternative
CC-99282
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase; Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/golcadomide.html
Concentration
10mM
Purity
98.04
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(C=C(C=C1)CN2CC(N3CCOCC3)C2)=C1CNC4=C5C(C(N([C@]6([H])C(NC(CC6)=O)=O)C5=O)=O)=CC=C4
Molecular Formula
C28H30FN5O5
Molecular Weight
535.57
Precautions
H302, H315, H319, H335
References & Citations
[1]J.-M. Michot, et al. A PHASE 1, MULTICENTER, OPEN-LABEL STUDY OF CC-99282 ALONE AND IN COMBINATION WITH RITUXIMAB IN PATIENTS WITH RELAPSED OR REFRACTORY NON-HODGKIN LYMPHOMAS. Hematological Oncology. Volume 39, Issue S2, Jun. 2021.|[2]Carrancio S, et al. CC-99282 is a novel cereblon (CRBN) E3 ligase modulator (CELMoD) agent with enhanced tumoricidal activity in preclinical models of lymphoma[J]. Blood, 2021, 138: 1200.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Cereblon

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T63771-01Golcadomide

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