Golcadomide

CAT: 0127-BUP09322-02Size: 10 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0127-BUP09322-02Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

2379572-34-4

Synonyms

CC-99282, CC 99282, CC99282

Purity

=98%

Smiles

N(CC1=C(F)C=C(CN2CC(C2)N3CCOCC3)C=C1)C4=C5C(C(=O)N(C5=O)[C@@H]6C(=O)NC(=O)CC6)=CC=C4

Chemical Information

Golcadomide

Golcadomide is a modulator of the E3 ubiquitin ligase complex containing cereblon (CRL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and antineoplastic activities. Upon administration, golcadomide specifically binds to cereblon (CRBN), thereby affecting the ubiquitin E3 ligase activity, and targeting certain substrate proteins for ubiquitination. This induces proteasome-mediated degradation of certain transcription factors, some of which are transcriptional repressors in T-cells. This leads to modulation of the immune system, including activation of T-lymphocytes, and downregulation of the activity of other proteins, some of which play key roles in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the CRL4-CRBN E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.

CAS Number	2379572-34-4
PubChem CID	146195299
IUPAC Name	2-[(3S)-2,6-dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione
Molecular Formula	C28H30FN5O5
Molecular Weight	535.6
XLogP	1.6
Topological Polar Surface Area	111
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Heavy Atom Count	39
Formal Charge	0
Complexity	970

SMILES

C1CC(=O)NC(=O)[C@H]1N2C(=O)C3=C(C2=O)C(=CC=C3)NCC4=C(C=C(C=C4)CN5CC(C5)N6CCOCC6)F

InChI

InChI=1S/C28H30FN5O5/c29-21-12-17(14-32-15-19(16-32)33-8-10-39-11-9-33)4-5-18(21)13-30-22-3-1-2-20-25(22)28(38)34(27(20)37)23-6-7-24(35)31-26(23)36/h1-5,12,19,23,30H,6-11,13-16H2,(H,31,35,36)/t23-/m0/s1

InChIKey

NZYDBVQXOGPDDU-QHCPKHFHSA-N

Chemical Structure

2D Structure

CAS: 2379572-34-4

CID: 146195299

Formula: C28H30FN5O5

MW: 535.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	535.6
XLogP3	1.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	535.22309724
Monoisotopic Mass	535.22309724
Topological Polar Surface Area	111 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	970
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
T63771-01	Golcadomide

Golcadomide

Chemical Information

Alternative Products

Popular Products