Procainamide (Standard)

CAT: 0804-HY-A0084AR-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0084AR-01Size:10 mg
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Description
Procainamide (Standard) is the analytical standard of Procainamide. This product is intended for research and analytical applications. Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research[1][2][3][4][5][6].
CAS Number
[51-06-9]
Product Name Alternative
Procaine amide (Standard) ; SP 100 (Standard)
UNSPSC
12352005
Target
DNA Methyltransferase; Potassium Channel; Reference Standards
Type
Reference compound
Related Pathways
Epigenetics; Membrane Transporter/Ion Channel; Others
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/procainamide-standard.html
Smiles
O=C(NCCN(CC)CC)C1=CC=C(N)C=C1
Molecular Formula
C13H21N3O
Molecular Weight
235.33
References & Citations
[1]Lee BH, et al. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem. 2005;280 (49) :40749-40756.|[2]Pritchard B, et al. Procainamide. [Updated 2021 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2022 Jan-.|[3]Gardner I, et al. A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo[J]. Chemical research in toxicology, 2005, 18 (9) : 1384-1394.|[4]Nakahara T, et al. Involvement of K+ channel in procainamide-induced relaxation of bovine tracheal smooth muscle[J]. European journal of pharmacology, 2000, 402 (1-2) : 143-149.|[5]Morissette G, et al. Massive cell vacuolization induced by organic amines such as procainamide[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 310 (1) : 395-406.|[6]Segura-Pacheco B, et al. Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy[J]. Clinical Cancer Research, 2003, 9 (5) : 1596-1603.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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