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Procainamide

CAT: 0804-HY-A0084A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0084A-01Size:100 mg
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Description
Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research[1][2][3][4][5][6].
CAS Number
51-06-9
Product Name Alternative
Procaine amide; SP 100
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
DNA Methyltransferase; Potassium Channel
Type
Reference compound
Related Pathways
Epigenetics; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/procainamide.html
Purity
99.80
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NCCN(CC)CC)C1=CC=C(N)C=C1
Molecular Formula
C13H21N3O
Molecular Weight
235.33
Precautions
H301, H315, H319, H335
References & Citations
[1]Lee BH, et al. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem. 2005;280 (49) :40749-40756.|[2]Pritchard B, et al. Procainamide. [Updated 2021 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2022 Jan-.|[3]Gardner I, et al. A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo[J]. Chemical research in toxicology, 2005, 18 (9) : 1384-1394.|[4]Nakahara T, et al. Involvement of K+ channel in procainamide-induced relaxation of bovine tracheal smooth muscle[J]. European journal of pharmacology, 2000, 402 (1-2) : 143-149.|[5]Morissette G, et al. Massive cell vacuolization induced by organic amines such as procainamide[J]. Journal of Pharmacology and Experimental Therapeutics, 2004, 310 (1) : 395-406.|[6]Segura-Pacheco B, et al. Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy[J]. Clinical Cancer Research, 2003, 9 (5) : 1596-1603.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Adv Sci (Weinh) . 2024 Dec 5:e2410360.|Environ Pollut. 2023 Sep 1:332:121931.|Free Radic Biol Med. 2024 Jun 1:S0891-5849 (24) 00506-9.|Clin Chem. 2019 Dec;65 (12) :1522-1531. |Patent. US20180263995A1.

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