Kaliotoxin

• UNSPSC Description:

  Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability[1][2].

• Target Antigen:

  Potassium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/kaliotoxin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(NCC(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]4CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N6[C@@H](CCC6)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]3CC7=CNC=N7)=O)NC4=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N8[C@H]5CCC8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

• Molecular Weight:

  4149.94

• References & Citations:

  [1]M Crest, et al. Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom. J Biol Chem. 1992 Jan 25;267(3):1640-7. |[2]S Kourrich, et al. Kaliotoxin, a Kv1.1 and Kv1.3 channel blocker, improves associative learning in rats. Behav Brain Res. 2001 Apr 8;120(1):35-46.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  145199-73-1