Anti-Serum Amyloid P / APCS(APCS/3240), CF405S conjugate
CAT:
37-BNC043240-500
Size:
500 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-Serum Amyloid P / APCS(APCS/3240), CF405S conjugate
- Description: Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer's disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: 9.5S alpha 1 glycoprotein; Amyloid P component serum (APCS); Pentaxin related; Pentraxin 2 (PTX2); Serum Amyloid P (SAP); Serum amyloid P component
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: APCS
- Gene ID: 325
- NCBI Gene ID: 507080
- UniProt: P02743
- Cellular Locus: Secreted (extracellular)
- Host: Mouse
- Species Reactivity: Human
- Immunogen: Recombinant fragment of human APCS protein (around aa 143-223) (exact sequence is proprietary)
- Target Antigen: APCS | Serum Amyloid P
- Clonality: Monoclonal
- Isotype: IgG2b κ
- Clone: APCS/3240
- Conjugation: CF405S
- Source: Animal
- Applications: IHC, FFPE (verified)
- Validated Applications: IHC, FFPE
- Positive Control: Human endometrial carcinoma tissue (IHC).
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: 200 kDa (oligomeric); 26 kDa (non-covalently bound subunit); 30 kDa (glycosylated SAP subunit)
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years