Anti-LMO2 (B-Cell Marker)(LMO2/3147R), CF405S conjugate

• Description:

  The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymph-angiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma. The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin. LMO2 is useful in differentiating follicular lymphoma (LMO2 ) from nodal marginal zone lymphoma (LM02-). It also is positive in Hodgkin's and Burkitt's lymphomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; RBTN L1; RBTN2; Rhombotin like 1; Rhombotin-2 (RHOM2); T-cell translocation protein 2; TTG2

• CAS Number:

  9007-83-4

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  LMO2

• Gene ID:

  4005

• NCBI Gene ID:

  34560

• UniProt:

  P25791

• Cellular Locus:

  Nucleus

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant fragment (around aa 23-140) human LMO2 protein (exact sequence is proprietary)

• Target Antigen:

  LMO2

• Clonality:

  Recombinant Monoclonal

• Isotype:

  IgG

• Clone:

  LMO2/3147R

• Conjugation:

  CF405S

• Disease:

  Tumor

• Source:

  Animal

• Applications:

  Flow, intracellular (verified) | IF (verified)

• Validated Applications:

  FC, IF

• Positive Control:

  K562, Ramos or Raji cells. Placenta, pancreas or Hodgkin s lymphoma.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  24 kDa

• Additionnal Information:

  Flow cytometry: 1-2 ug/million cells; Immunofluorescence: 1-2 ug/mL; Optimal dilution for a specific application should be determined.|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years