Anti-BMI1 (Oncogene and Stem Cell Marker)(BMI1/2823)

Anti-BMI1 (Oncogene and Stem Cell Marker)(BMI1/2823)

• Description: The B cell-specific moloney murine leukemia virus integration site 1 (Bmi-1) is a transcriptional receptor of the polycomb gene family involved in several cellular processes including cell-cycle regulation, apoptosis, and maintenance of adult and neoplastic stem cells by providing self-renewal capacity. Further, Bmi-1 expression has been associated with malignant transformation, tumor progression, metastatic disease, and poor prognosis in human malignancies. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: BMI1; Polycomb complex protein BMI1; B lymphoma Mo MLV insertion region 1 homolog; BMI1 polycomb ring finger oncogene; Polycomb group ring finger 4; RING finger protein 51
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: BMI1
• Gene ID: 648
• NCBI Gene ID: 380403
• UniProt: P35226
• Cellular Locus: Cytoplasmic|Nucleus
• Host: Mouse
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant fragment (around aa 142-326) of human BMI1 protein (exact sequence is proprietary)
• Target Antigen: BMI1
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Clone: BMI1/2823
• Conjugation: Purified, BSA-free
• Source: Animal
• Applications: IF (verified) | IHC, FFPE (verified) | WB (verified)
• Validated Applications: IF, IHC, FFPE, WB
• Field of Research: Cancer, Developmental biology
• Positive Control: HeLa or Jurkat cells. Colon Carcinoma.
• Concentration: 1 mg/mL
• Buffer: PBS, no BSA, no azide
• Molecular Weight: ~41 kDa
• Shipping Conditions: Room temperature
• Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years