Anti-Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker)(CPTC-AKR1B1-2)

• Description:

  Aldo-keto Reductase Family 1 Member B1 (AKR1B1), also known as aldose reductase or aldehyde reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  Aldo-keto reductase family 1 member B1; AKR1B1; Aldehyde Reductase 1; Aldose reductase; Lii5-2 CTCL tumor antigen; low Km aldose reductase

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  AKR1B1

• Gene ID:

  231

• NCBI Gene ID:

  521212

• UniProt:

  P15121

• Cellular Locus:

  Cytoplasmic

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant full-length human AKR1B1 protein

• Target Antigen:

  Aldo-keto Reductase Family 1 Member B1

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Clone:

  CPTC-AKR1B1-2

• Conjugation:

  Purified, with BSA

• Source:

  Animal

• Applications:

  IF (verified) | IHC, FFPE (verified) | WB (verified)

• Validated Applications:

  IF, IHC, FFPE, WB

• Positive Control:

  549, 293T, A431, HeLa, HepG2, MOLT4 and Raji whole cell lysates; HeLa cells; Human colon carcinoma tissue.

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight:

  37 kDa

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4