Anti-RCAS1 / Estrogen Receptor Binding Site Associated, Antigen 9(CPTC-EBAG9-2), CF405S conjugate

Anti-RCAS1 / Estrogen Receptor Binding Site Associated, Antigen 9(CPTC-EBAG9-2), CF405S conjugate

• Description: EBAG9, also known as RCAS1, is an estrogen-transcribed protein. Soluble and membranous RCAS1 proteins may play a role in the immune escape of tumor cells by promoting T lymphocyte inhibition of growth and apoptosis. RCAS1 is expressed in a wide variety of cancers, including uterine, ovarian, and lung cancer cells, and acts as a ligand for a putative receptor present on peripheral lymphocytes. RCAS1 is highly expressed not only in cancer cells but also in non-tumor bile duct cells subject to immune attack. RCAS1 inhibits the in vitro growth of receptor-expressing cells and induces apoptosis, contributing to the ability of tumor cells to evade host immune surveillance. High expression of RCAS1 significantly correlates with tumor progression and with poor outcome for many cancer patients. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: BAG9; cancer associated surface antigen; cancer associated surface antigen RCAS1; EB9; estrogen receptor binding fragment associated gene 9; PDAF; receptor binding cancer antigen expressed on SiSo cells
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: EBAG9
• Gene ID: 9166
• NCBI Gene ID: 409368
• UniProt: O00559
• Cellular Locus: Golgi apparatus
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Recombinant full-length human EBAG9 protein
• Target Antigen: Estrogen Receptor Binding Site Associated, Antigen 9 | RCAS1
• Clonality: Monoclonal
• Isotype: IgG2a κ
• Clone: CPTC-EBAG9-2
• Conjugation: CF405S
• Source: Animal
• Applications: IHC, FFPE (verified) | WB (verified)
• Validated Applications: IHC, FFPE, WB
• Positive Control: MCF-7, Jurkat; 293 cell lysates; Human skeletal muscle tissue.
• Concentration: 0.1 mg/mL
• Buffer: PBS, 0.1% BSA, 0.05% azide
• Molecular Weight: 32 kDa
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years