Anti-BAP1 (BRCA1 Associated Protein 1)(BAP1/2431)

• Description:

  The BRCA 1 Associated Protein 1 (BAP1) protein belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  BAP1; BRCA1 associated protein 1; Cerebral protein 13; Cerebral protein 6; HUCEP 13; Hucep 6; Ubiquitin carboxy terminal hydrolase; Ubiquitin carboxyl terminal hydrolase BAP1; UCHL2

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  BAP1

• Gene ID:

  8314

• NCBI Gene ID:

  106674

• UniProt:

  Q92560

• Cellular Locus:

  Cytoplasmic|Nucleus

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant human BAP1 protein fragment (around aa 191-326) (exact sequence is proprietary)

• Target Antigen:

  BAP1

• Clonality:

  Monoclonal

• Isotype:

  IgG2c κ

• Clone:

  BAP1/2431

• Conjugation:

  Purified, with BSA

• Source:

  Animal

• Field of Research:

  Ubiquitination

• Positive Control:

  Jurkat or PC-3 or HepG2 cells. Testis, Placenta, Ovarian or Breast Carcinoma.

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS, 0.05% BSA, 0.05% azide

• Molecular Weight:

  91 kDa

• Additionnal Information:

  For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4