BAP1 Antibody / BRCA1-Associated Protein 1

• Description:

  The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

• Specifications:

  ELISA (order BSA/sodium azide-free format for coating)

• UniProt:

  Q92560

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 191-326 from the human protein was used as the immunogen for the BAP1 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2c κ

• Clone:

  BAP1/2432

• Applications:

  ELISA

• Purity:

  Protein G affinity chromatography

• Format:

  Purified

• Buffer:

  0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Reconstitution:

  Store the BAP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This BAP1 antibody is available for research use only.

• Storage Conditions:

  Store the BAP1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

• Formulation:

  0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

• CAS Number:

  9007-83-4

• Location:

  Nuclear, cytoplasmic