Anti-NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)(NX2/2198R)
CAT:
37-BNUB2198-100
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)(NX2/2198R)
- Description: Expression of NKX2. 2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2. 2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Synonyms: Homeobox protein NK-2 homolog B; NK2 transcription factor like protein B; NK2 transcription factor related locus 2; NKX22; Nkx2b; tinman
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: NKX2-2
- Gene ID: 4821
- NCBI Gene ID: 516922
- UniProt: O95096
- Cellular Locus: Nucleus
- Host: Rabbit
- Species Reactivity: Human
- Immunogen: Recombinant human NKX2.2 protein fragment (around aa1-119) (exact sequence is proprietary)
- Target Antigen: NKX2.2
- Clonality: Monoclonal
- Isotype: IgG
- Clone: NX2/2198R
- Conjugation: Purified, with BSA
- Disease: Tumor
- Source: Animal
- Applications: IHC, FFPE (verified)
- Validated Applications: IHC, FFPE
- Positive Control: Pancreas or Ewing's sarcoma
- Concentration: 0.2 mg/mL
- Buffer: PBS, 0.05% BSA, 0.05% azide
- Molecular Weight: 40-50 kDa
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years