NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)

• Gene Name:

  [NKX2.2]

• NCBI Gene ID:

  4821

• Reactivity:

  Human. Others not known.

• Storage Conditions:

  Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential small round cell tumors.

• Other Gene Names:

  [NKX2-2; NKX2-2; NKX2B; NKX2.2; NKX2.2; NKX2B]

• Short Name:

  [NKX2.2]

• Other Product Names:

  [homeobox protein Nkx-2.2; Homeobox protein Nkx-2.2; homeobox protein Nkx-2.2; NK2 homeobox 2; Homeobox protein NK-2 homolog B]

• NCBI GI Number:

  4505401

• NCBI Accession Number:

  NP_002500.1

• NCBI GB Accession Number:

  NM_002509.3

• Uniprot Accession Number:

  O95096