Anti-NK1.1 / CD161c / Klrb1c, Mouse(PK136)

Anti-NK1.1 / CD161c / Klrb1c, Mouse(PK136)

• Description: NK1. 1 is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by theKlrb1c/NKR-P1Cgene. It is predominantly expressed as a disulfide-linked homodimer on NK cells however; it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1. 1 is expressed in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allograftsin vivo. NK-1. 1 has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. NK-1. 1 is commonly used as a mouse NK cell marker. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
• Synonyms: CD161 antigen-like family member C; CD161c; Killer cell lectin-like receptor subfamily B member 1C (Klrb1c); Klrb1f; Lymphocyte antigen 55c (Ly55c); Lymphocyte antigen 59; Natural killer cell surface protein P1-40; NK1.1; NKR-P1 40; NKR-P1.9; NKR-P1C; NKRP1
• CAS Number: 9007-83-4
• UNSPSC: 41116161
• UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
• Gene Name: Klrb1c (Mouse)
• Gene ID: 17059
• NCBI Gene ID: 480764
• UniProt: P27814
• Cellular Locus: Plasma membrane
• Host: Mouse
• Species Reactivity: Mouse
• Immunogen: CD Mouse spleen and bone marrow cells enriched for NK-1 cells
• Target Antigen: CD161c | Klrb1c, | NK1.1
• Clonality: Monoclonal
• Isotype: IgG2a κ
• Clone: PK136
• Conjugation: Purified, BSA-free
• Source: Animal
• Applications: Flow, surface (published) | Functional studies (published)
• Validated Applications: FC, Functional assays
• Positive Control: MPBMC's or Thymus or Lymph Node.
• Concentration: 1 mg/mL
• Buffer: PBS, no BSA, no azide
• Molecular Weight: kDa
• References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. J Exp Med (1993) 178: 223-229. (functional studies; Flow, surface)
• Shipping Conditions: Room temperature
• Storage Conditions: -35°C to -5°C ; Stable at room temperature or 37°C (98°F) for 7 days.
• Shelf Life: 2 years