Anti-NK1.1 / CD161c / Klrb1c, Mouse(PK136), CF647 conjugate

• Description:

  NK1. 1 is a type II integral membrane glycoprotein with a C-type lectin domain and is encoded by theKlrb1c/NKR-P1Cgene. It is predominantly expressed as a disulfide-linked homodimer on NK cells however; it is also expressed on NK-T cells, a rare population of T lymphocytes. NK1. 1 is expressed in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allograftsin vivo. NK-1. 1 has also been shown to play a role in NK cell activation, IFN- production, and cytotoxic granule release. NK-1. 1 is commonly used as a mouse NK cell marker. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  CD161 antigen-like family member C; CD161c; Killer cell lectin-like receptor subfamily B member 1C (Klrb1c); Klrb1f; Lymphocyte antigen 55c (Ly55c); Lymphocyte antigen 59; Natural killer cell surface protein P1-40; NK1.1; NKR-P1 40; NKR-P1.9; NKR-P1C; NKRP1

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  Klrb1c (Mouse)

• Gene ID:

  17059

• NCBI Gene ID:

  480764

• UniProt:

  P27814

• Cellular Locus:

  Plasma membrane

• Host:

  Mouse

• Species Reactivity:

  Mouse

• Immunogen:

  CD Mouse spleen and bone marrow cells enriched for NK-1 cells

• Target Antigen:

  CD161c | Klrb1c, | NK1.1

• Clonality:

  Monoclonal

• Isotype:

  IgG2a κ

• Clone:

  PK136

• Conjugation:

  CF647

• Source:

  Animal

• Applications:

  Flow, surface (published) | Functional studies (published)

• Validated Applications:

  FC, Functional assays

• Positive Control:

  MPBMC's or Thymus or Lymph Node.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  kDa

• References & Citations:

  Note: References for this clone sold by other suppliers may be listed for expected applications. J Exp Med (1993) 178: 223-229. (functional studies; Flow, surface)

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4