Anti-IL-10R1, Mouse (Interleukin-10 Receptor 1) (CD210)(1B1.3a), Biotin conjugate

• Description:

  This monoclonal antibody recognizes Mouse Interleukin-10 receptor 1 (IL-10R1), a cell surface glycoprotein of approximately 110 kDa. Its epitope is localized in the ligand-binding domain in the extracellular region of Mouse IL-10R1. This antibody blocks the binding of IL-10 to its receptor. IL-10R1 is a class II cytokine receptor expressed on thymocytes, T cells, B cells, NK cells, monocytes and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that leads to B cell proliferation and inhibition of macrophage activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  CD210 antigen; CDw210a; IBD28; IL10R alpha; IL-10R subunit 1; IL-10R1; IL10RA IL10RIL-10R subunit alpha; interleukin 10 receptor; alpha; interleukin-10 receptor alpha chain; Interleukin-10 receptor subunit 1

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene ID:

  16154

• NCBI Gene ID:

  379327

• UniProt:

  Q61727

• Cellular Locus:

  Plasma membrane

• Host:

  Rat

• Species Reactivity:

  Mouse

• Immunogen:

  Purified recombinant extracellular region of Mouse IL10RA

• Target Antigen:

  IL-10R1,

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Clone:

  1B1.3a

• Conjugation:

  Biotin

• Source:

  Animal

• Applications:

  Flow, surface (published) | Functional studies (published)

• Validated Applications:

  FC, Functional assays

• Positive Control:

  MPBMC's. Spleen, Thymus, Lymph Node, Placenta, Lung or Liver.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  90-110 kDa

• References & Citations:

  Note: References for this clone sold by other suppliers may be listed for expected applications. J Immunol (2008) 181:5545-5550. (neutralization) PLoS One (2017) 12(10): e0186317. (Flow, surface)

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4