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Anti-CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10)

CAT:
37-BNUB1696-100
Size:
100 µL
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Anti-CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10) - image 1
Anti-CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10) - image 2
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Anti-CTLA4 / CD152 (Negative Regulator of T-Cells)(L4P2F5.F10)

  • Description: CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. The novel finding that CTLA-4 molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Synonyms: ALPS5; CD152; Celiac disease 3 (CELIAC3); Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4); GRD4; GSE; ICOS; Insulin-dependent Diabetes Mellitus 12 (IDDM12)
  • CAS Number: 9007-83-4
  • UNSPSC: 41116161
  • UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
  • Gene Name: CTLA4
  • Gene ID: 1493
  • NCBI Gene ID: 247824
  • UniProt: P16410
  • Cellular Locus: Plasma membrane|Secreted (extracellular)
  • Host: Mouse
  • Species Reactivity: Cow, Human, Mouse, Rat
  • Immunogen: A synthetic peptide from CTLA4 (exact sequence is proprietary)
  • Target Antigen: CD152 | CTLA4
  • Clonality: Monoclonal
  • Isotype: IgG1 κ
  • Clone: L4P2F5.F10
  • Conjugation: Purified, with BSA
  • Source: Animal
  • Positive Control: Jurkat or Raji cells. Lymph Node or Tonsil.
  • Concentration: 0.2 mg/mL
  • Buffer: PBS, 0.05% BSA, 0.05% azide
  • Molecular Weight: 30-43 kDa
  • Additionnal Information: For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry
  • Shipping Conditions: Room temperature
  • Storage Conditions: 4°C; Stable at room temperature or 37°C (98°F) for 7 days.
  • Shelf Life: 2 years

Datasheet

MSDS