Anti-Angiotensin I Converting Enzyme (ACE) / CD143(9B9), CF568 conjugate

• Description:

  Angiotensin-converting enzyme (ACE), also known as CD143, encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  angiotensin 1 converting enzyme; angiotensin-converting enzyme; ACE; carboxycathepsin; CD143; dipeptidyl carboxypeptidase 1; Kininase II; peptidase P

• CAS Number:

  9007-83-4

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  ACE

• Gene ID:

  1636

• NCBI Gene ID:

  298469

• UniProt:

  P12821

• Cellular Locus:

  Plasma membrane

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Full-length recombinant human ACE/CD143 protein

• Target Antigen:

  Angiotensin I Converting Enzyme | CD143

• Clonality:

  Monoclonal

• Isotype:

  IgG1 κ

• Clone:

  9B9

• Conjugation:

  CF568

• Source:

  Animal

• Applications:

  IHC, FFPE (verified)

• Validated Applications:

  IHC, FFPE

• Positive Control:

  Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% BSA, 0.05% azide

• Molecular Weight:

  195 kDa

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years