Anti-Angiotensin Converting Enzyme Antibody

• Description:

  Mouse Monoclonal Antibody specific to Angiotensin Converting Enzyme Human

• Product Name Alternative:

  ACE, EC 3.2.1.-, EC 3.4.15.1, Dipeptidyl carboxypeptidase I, Kininase II, CD antigen CD143 [Cleaved into: Angiotensin-converting enzyme, soluble form]

• Gene Name:

  ACE

• NCBI Gene ID:

  ACE

• UniProt:

  P12821

• Cellular Locus:

  [Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Bovine

• Immunogen:

  ACE purified from rat lung.

• Target Antigen:

  Angiotensin-converting enzyme

• Target:

  Angiotensin Converting Enzyme

• Clonality:

  Monoclonal

• Isotype:

  IgM

• Type:

  Antibody

• Applications:

  ELISA, IHC, FACS

• Field of Research:

  Enzymes

• Purification Method:

  PEG Purified

• Concentration:

  Lot Specific

• Dilution:

  Dilute in PBS or medium that is identical to that used in the assay system.

• Format:

  Purified

• Form:

  Liquid

• Buffer:

  Phosphate Buffered Saline

• Function:

  Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

• Additionnal Information:

  This antibody may be used in ELISA,
  
  Immunohistochemistry, and flow cytometry for detection of ACE or ACE-positive cells. Other applications are under investigation.

• Storage Conditions:

  These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

• Specificity:

  This antibody reacts specifically with human, bovine, and murine ACE and with ACE-positive endothelial cells.

  DILUTION INSTRUCTIONS

  Dilute in PBS or medium which is identical to that used in the assay system.

  STORAGE AND STABILITY

  These antibodies are stable for at least one (1) year at -20oC to -70oC. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

  REFERENCE

  Auerbach, R. et al. (1982) Proc NatlAcad Sci USA 79: 7891.For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures

• Formulation:

  PBS, pH 7.4.

• Buffer pH:

  pH 7.4

• CAS Number:

  9007-83-4