Dapivirine-d11

Dapivirine-d11

• CAS Number: 1329613-10-6
• UNSPSC Description: Dapivirine-d11 is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[1][2].
• Target Antigen: Apoptosis; Autophagy; HIV; Isotope-Labeled Compounds; Reverse Transcriptase
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Apoptosis;Autophagy;Others
• Field of Research: Infection
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=CC=C(NC2=NC=CC(NC3=C(C([2H])([2H])[2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C3C([2H])([2H])[2H])=N2)C=C1
• Molecular Weight: 340.47
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Weiwen Liu, et al. Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma. J Cancer. 2018 Jan 1;9(1):117-128.|[3]Bríd Devlin, et al. Development of dapivirine vaginal ring for HIV prevention. Antiviral Res. 2013 Dec;100 Suppl:S3-8.|[4]Yven Van Herrewege, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9.|[5]Michael E Halwes, et al. Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans. Eur J Pharm Sci. 2016 Oct 10;93:410-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported