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Amino-PEG3-C2-acid

CAT: 0804-HY-W040165-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W040165-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
CAS Number
784105-33-5
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amino-peg3-c2-acid.html
Purity
99.94
Solubility
DMF : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)CCOCCOCCOCCN
Molecular Formula
C9H19NO5
Molecular Weight
221.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Kevin HAMBLETT, et al. Anti-her2 biparatopic antibody-drug conjugates and methods of use. WO2019173911A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; PEG Linkers

Chemical Information

3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)propanoic acid
CAS Number784105-33-5
PubChem CID11608245
IUPAC Name3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoic acid
Molecular FormulaC9H19NO5
Molecular Weight221.25
XLogP-3.9
Topological Polar Surface Area91
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Heavy Atom Count15
Formal Charge0
Complexity153
SMILES
C(COCCOCCOCCN)C(=O)O
InChI
InChI=1S/C9H19NO5/c10-2-4-14-6-8-15-7-5-13-3-1-9(11)12/h1-8,10H2,(H,11,12)
InChIKey
XUQZKSCQPMNDEY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)propanoic acid
CAS: 784105-33-5
CID: 11608245
Formula: C9H19NO5
MW: 221.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight221.25
XLogP3-3.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Exact Mass221.12632271
Monoisotopic Mass221.12632271
Topological Polar Surface Area91 Ų
Heavy Atom Count15
Formal Charge0
Complexity153
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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