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β-Spaglumic acid

CAT: 0804-HY-130553-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130553-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 μM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus) . β-Spaglumic acid can be used in neuroprotection-related studies[1][2].
CAS Number
4910-46-7
Product Name Alternative
β-NAAG; β-N-Acetylaspartylglutamic acid
UNSPSC
12352211
Target
Aminopeptidase; mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/β-spaglumic-acid.html
Purity
99.97
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C[C@@H](C(O)=O)NC(C)=O)=O
Molecular Formula
C11H16N2O8
Molecular Weight
304.25
References & Citations
[1]Yourick DL, et al. N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures. Brain Res. 2003 Nov 21;991 (1-2) :56-64. |[2]Wroblewska B, et al. β-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor. J Neurophysiol. 2001 Mar;85 (3) :1097-106.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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