Limaprost-d3

• Description:

  Limaprost-d3 (17α,20-dimethyl-δ2-PGE1-d3) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research[1][2].

• UNSPSC:

  12352211

• Hazard Statement:

  H300-H315-H319

• Target:

  Isotope-Labeled Compounds; PGE synthase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Immunology/Inflammation; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  C (CCCC=CC (O) =O) [C@@H]1[C@@H] (C=C[C@H] (C[C@H] (CCCC) [C@] ([2H]) ([2H]) [2H]) O) [C@H] (O) CC1=O

• Molecular Formula:

  C22H33D3O5

• Molecular Weight:

  383.54

• Precautions:

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P405-P501

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Tsuboi T, et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn Ther. 1980 Sep;247 (1) :89-102.|[3]Swainston Harrison T, et al. Limaprost. Drugs. 2007;67 (1) :109-18; discussion 119-20.|[4]Murata K, et al. PGE1 Attenuates IL-1β-induced NGF Expression in Human Intervertebral Disc Cells. Spine (Phila Pa 1976) . 2016 Jun;41 (12) :E710-6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1263190-37-9