Pyrazinamide

Pyrazinamide

• CAS Number: 98-96-4
• UNSPSC Description: Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
• Target Antigen: Antibiotic; Autophagy; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection;Autophagy
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/pyrazinamide.html
• Purity: 99.97
• Solubility: DMSO : ≥ 50 mg/mL|H2O : 6.67 mg/mL (ultrasonic)
• Smiles: O=C(C1=NC=CN=C1)N
• Molecular Weight: 123.11
• References & Citations: [1]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181(7):2044-9.|[2]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2(4):MGM2-0023-2013.
• Shipping Conditions: Room Temperature
• Storage Conditions: Store at room temperature 3 years
• Clinical Information: Launched