TWEAK/TNFSF12, Rat (HEK293, Fc)

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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MBS8116438-02	Mouse TWEAK/TNFSF12 HEK293 Overexpression Lysate
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MBS517734-01	TWEAK (TNFSF12)
MBS8116437-01	Mouse TWEAK/TNFSF12 HEK293 Overexpression Lysate
MBS8116437-02	Mouse TWEAK/TNFSF12 HEK293 Overexpression Lysate
MBS8117804-01	Cynomolgus TWEAK/TNFSF12 HEK293 Overexpression Lysate

CAT:

804-HY-P77266-01

Size:

5 µg

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TWEAK/TNFSF12, Rat (HEK293, Fc)

UNSPSC Description: TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis[1]. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs)[2]. TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1[3]. TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain. TWEAK/TNFSF12 Protein, Rat (HEK293, Fc) is produced by HEK293 cells (R105-H249) with N-terminal rFc-tag.
Type: Recombinant Proteins
Assay Protocol: https://www.medchemexpress.com/cytokines/tweak-tnfsf12-protein-rat-hek293-fc.html
Purity: 96.20
Smiles: RAIAAHYEVH PQPGQDGAQA GVDGTVSGWE ETKINSSSPL RYDRQIGEFT VIRAGLYYLY CQVHFDEGKA VYLKLDLLVN GVLALRCLEE FSATAASSPG PQLRLCQVSG LLPLRPGSSL RIRTLPWAHL KAAPFLTYFG LFQVH
Molecular Weight: Approximately 50 kDa
References & Citations: [1]Wiley SR, et al. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):241-9.|[2]Lammens A, et al. Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding. PLoS One. 2013 May 8;8(5):e62697.|[3]Lynch CN, et al. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999 Mar 26;274(13):8455-9.|[4]Yang B, et al. TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner. Am J Transl Res. 2016 Sep 15;8(9):3848-3860.
Shipping Conditions: Blue Ice
Storage Conditions: Stored at -20°C for 2 years

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Cat	Name
HY-P77264-03	TWEAK/TNFSF12, Mouse (HEK293, Fc)
HY-P77266-01	TWEAK/TNFSF12, Rat (HEK293, Fc)
HY-P77265-03	TWEAK/TNFSF12, Mouse (HEK293, rFc)
HY-P77265-01	TWEAK/TNFSF12, Mouse (HEK293, rFc)
HY-P77264-01	TWEAK/TNFSF12, Mouse (HEK293, Fc)
HY-P77266-03	TWEAK/TNFSF12, Rat (HEK293, Fc)
HY-P701045-02	TWEAK/TNFSF12, Human (HEK293, hFc)
HY-P701045-01	TWEAK/TNFSF12, Human (HEK293, hFc)
HY-P77264-02	TWEAK/TNFSF12, Mouse (HEK293, Fc)
HY-P77266-02	TWEAK/TNFSF12, Rat (HEK293, Fc)