TWEAK/TNFSF12, Mouse (HEK293, Fc)

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAT:

804-HY-P77264-03

Size:

2 µg

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TWEAK/TNFSF12, Mouse (HEK293, Fc)

UNSPSC Description: TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis[1]. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs)[2]. TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1[3]. Mouse TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (25-45 a.a.). TWEAK/TNFSF12 Protein, Mouse (HEK293, Fc) is the extracellular part (R105-H249) of TWEAK protein, produced by HEK293 cells (R105-H249) with N-terminal hFc-tag.
Type: Recombinant Proteins
Assay Protocol: https://www.medchemexpress.com/cytokines/tweak-tnfsf12-protein-mouse-hek293-fc.html
Purity: 93.00
Smiles: RAIAAHYEVH PRPGQDGAQA GVDGTVSGWE ETKINSSSPL RYDRQIGEFT VIRAGLYYLY CQVHFDEGKA VYLKLDLLVN GVLALRCLEE FSATAASSPG PQLRLCQVSG LLPLRPGSSL RIRTLPWAHL KAAPFLTYFG LFQVH
Molecular Weight: Approximately 42.95-50 kDa due to the glycosylation as determined by reducing SDS-PAGE; Approximately 90-110 kDa as determined by non-reducing SDS-PAGE.
References & Citations: [1]Wiley SR, et al. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):241-9.|[2]Lammens A, et al. Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding. PLoS One. 2013 May 8;8(5):e62697.|[3]Lynch CN, et al. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999 Mar 26;274(13):8455-9.|[4]Moreno JA, et al. The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB. J Am Soc Nephrol. 2011 Jul;22(7):1315-25.|[5]Harada N, et al. Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2002 Dec 6;299(3):488-93.
Shipping Conditions: Blue Ice
Storage Conditions: Stored at -20°C for 2 years

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HY-P77264-03	TWEAK/TNFSF12, Mouse (HEK293, Fc)
HY-P77265-03	TWEAK/TNFSF12, Mouse (HEK293, rFc)
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HY-P77264-02	TWEAK/TNFSF12, Mouse (HEK293, Fc)
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