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RK-682 (hemicalcium)

CAT: 0804-HY-135564Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-135564Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RK-682 hemicalcium is the hemicalcium salt form of RK-682. RK-682 hemicalcium is the inhibitor for protein tyrosine phosphatase (PTPase), heparanase, phospholipase A2 and HIV-1 protease. RK-682 hemicalcium inhibits the dephosphorylation of CD45 (IC50 is 54 μM) and VHR (IC50 is 2.0 μM), and thereby inhibits the ERK signaling pathway. RK-682 hemicalcium inhibits the cell viability of cancer cell MGH-U3, T24 and UROtsa with IC50s of 78.2, 43.2 and 145 nM, respectively, arrests the cell cycle at G1/S phase, inhibits the cell migration and autophagy in MGH-U3 and T24[1][2][3].
CAS Number
332131-32-5
UNSPSC
12352005
Target
Autophagy; ERK; HIV Protease; Phosphatase; Phospholipase
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/rk-682-hemicalcium.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCCCCCCC(C1=C([C@@H](CO)OC1=O)O)=O.[1/2].[Ca]
Molecular Formula
C21H36O5.1/2Ca
Molecular Weight
408.59
References & Citations
[1]Usui T, et al., Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition. Chem Biol. 2001 Dec;8 (12) :1209-20.|[2]Hamaguchi T, et al., RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. FEBS Lett. 1995 Sep 18;372 (1) :54-8. |[3]Tatsumi Y, et al., Inhibition of Heparanase Expression Results in Suppression of Invasion, Migration and Adhesion Abilities of Bladder Cancer Cells. Int J Mol Sci. 2020 May 27;21 (11) :3789.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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