p-MPPI (hydrochloride)

p-MPPI (hydrochloride)

• CAS Number: 220643-77-6
• UNSPSC Description: p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].
• Target Antigen: 5-HT Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/p-mppi-hydrochloride.html
• Purity: 99.81
• Solubility: DMSO : 17.86 mg/mL (ultrasonic)|H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C(C1=CC=C(C=C1)I)N(C2=NC=CC=C2)CCN3CCN(CC3)C4=CC=CC=C4OC.[H]Cl
• Molecular Weight: 578.87
• References & Citations: [1]Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.|[2]Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported